Niosomes as an Effective Phytochemical Nanocarrier: A short review
Keywords:
Niosomes, Method of Preparation, PhytochemicalsAbstract
Niosomes are a new class of nanocarrier systems for the delivery of phytochemicals made from biocompatible, stable, and hydrophilic and hydrophobic encapsulating non-ionic surface-active agents. This review looks at the role that niosomes can play in enhancing the solubility, stability, and bioavailability of the phytochemicals, as well as how they can be used for the therapy of targeted and controlled drug delivery. Nanocarriers are membranes around cells or tissues composed of electronically neutral lipids that protrude from a biological cell membrane and serve to increase efficacy of natural resources. This review looks at the variety of advancements as well as challenges existing in the quest for integrating Phytochemicals using liposomal technology and the perspectives on the way forward in enhancing the efficacy of Phytochemicals through liposomes. These advances also aim at giving a better understanding of this novel drug delivery system
References
Riaz M, Khalid R, Afzal M, Anjum F, Fatima H, Zia S, et al. Phytobioactive compounds as therapeutic agents for human diseases: A review. Food Sci Nutr. 2023;11(6):2500–29.
2. Chavda VP, Nalla LV, Balar P, Bezbaruah R, Apostolopoulos V, Singla RK, et al. Advanced phytochemical-based nanocarrier systems for the treatment of breast cancer. Cancers (Basel). 2023;15(4):1023.
3. Baishya R, Hati Boruah JL, Bordoloi MJ, Kumar D, Kalita P. Novel drug delivery system in phytochemicals: Modern era of ancient science. Herb Med India Indig Knowledge, Pract Innov its Value. 2020;175–89.
4. Barani M, Sangiovanni E, Angarano M, Rajizadeh MA, Mehrabani M, Piazza S, et al. Phytosomes as innovative delivery systems for phytochemicals: A comprehensive review of literature. Int J Nanomedicine. 2021;6983–7022.
5. Yeo PL, Lim CL, Chye SM, Ling APK, Koh RY. Niosomes: a review of their structure, properties, methods of preparation, and medical applications. Asian Biomed. 2017;11(4):301–14.
6. Chaw CS, Ah Kim KY. Effect of formulation compositions on niosomal preparations. Pharm Dev Technol. 2013;18(3):667–72.
7. Ahmad R, Srivastava S, Ghosh S, Khare SK. Phytochemical delivery through nanocarriers: A review. Colloids Surfaces B Biointerfaces. 2021;197:111389.
8. Uchegbu IF, Vyas SP. Non-ionic surfactant based vesicles (niosomes) in drug delivery. Int J Pharm. 1998;172(1–2):33–70.
9. Ritwiset A, Krongsuk S, Johns JR. Molecular structure and dynamical properties of niosome bilayers with and without cholesterol incorporation: A molecular dynamics simulation study. Appl Surf Sci. 2016;380:23–31.
10. Marianecci C, Di Marzio L, Rinaldi F, Celia C, Paolino D, Alhaique F, et al. Niosomes from 80s to present: the state of the art. Adv Colloid Interface Sci. 2014;205:187–206.
11. Aparajay P, Dev A. Functionalized niosomes as a smart delivery device in cancer and fungal infection. Eur J Pharm Sci. 2022;168:106052.
12. Mahale NB, Thakkar PD, Mali RG, Walunj DR, Chaudhari SR. Niosomes: novel sustained release nonionic stable vesicular systems—an overview. Adv Colloid Interface Sci. 2012;183:46–54.
13. Moammeri A, Chegeni MM, Sahrayi H, Ghafelehbashi R, Memarzadeh F, Mansouri A, et al. Current advances in niosomes applications for drug delivery and cancer treatment. Mater Today Bio. 2023;23:100837.
14. Barani M, Mirzaei M, Torkzadeh-Mahani M, Nematollahi MH. Lawsone-loaded Niosome and its antitumor activity in MCF-7 breast Cancer cell line: a Nano-herbal treatment for Cancer. DARU J Pharm Sci. 2018;26:11–7.
15. Thabet Y, Elsabahy M, Eissa NG. Methods for preparation of niosomes: A focus on thin-film hydration method. Methods. 2022;199:9–15.
16. Hajizadeh MR, Parvaz N, Barani M, Khoshdel A, Fahmidehkar MA, Mahmoodi M, et al. Diosgenin-loaded niosome as an effective phytochemical nanocarrier: Physicochemical characterization, loading efficiency, and cytotoxicity assay. DARU J Pharm Sci. 2019;27:329–39.
17. Shahbazi R, Jafari-Gharabaghlou D, Mirjafary Z, Saeidian H, Zarghami N. Design and optimization various formulations of PEGylated niosomal nanoparticles loaded with phytochemical agents: potential anti-cancer effects against human lung cancer cells. Pharmacol Reports. 2023;75(2):442–55.
18. Barani M, Mirzaei M, Torkzadeh-Mahani M, Adeli-Sardou M. Evaluation of carum-loaded niosomes on breast cancer cells: Physicochemical properties, in vitro cytotoxicity, flow cytometric, DNA fragmentation and cell migration assay. Sci Rep. 2019;9(1):7139.
19. Hajizadeh MR, Maleki H, Barani M, Fahmidehkar MA, Mahmoodi M, Torkzadeh-Mahani M. In vitro cytotoxicity assay of D-limonene niosomes: an efficient nano-carrier for enhancing solubility of plant-extracted agents. Res Pharm Sci. 2019;14(5):448–58.
20. Ghazwani M, Hani U, Alam A, Alqarni MH. Quality-by-design-assisted optimization of carvacrol oil-loaded niosomal gel for anti-inflammatory efficacy by topical route. Gels. 2023;9(5):401.