Integrative Ayurveda and Gut Microbiome Interventions: Toward Personalized Microbiome-Ayurveda Therapeutics
Keywords:
Ayurveda, , Gut Microbiome, Prakriti, TrifalaAbstract
ABSTRACT
The gut microbiome is now widely recognized as a central regulator of human health, influencing digestion, immunity, metabolism, and even neurobehavioral processes through the gut-brain axis. Ayurveda, the ancient Indian medical system, has long emphasized digestion (Agni), personalized constitutions (Prakriti), and rejuvenation therapies (Rasayana) as key determinants of health and disease. In recent years, converging evidence has highlighted remarkable parallels between these traditional frameworks and microbiome science. Emerging studies suggest that Ayurvedic classifications such as Prakriti are associated with specific gut microbial signatures, while classical polyherbal formulations such as Triphala, Tinospora cordifolia (Guduchi), and Withania somnifera (Ashwagandha) exert microbiome-modulating effects in animal models and early human trials. These interventions influence microbial composition, enhance short-chain fatty acid production, and regulate host immunity, providing mechanistic support for long-standing Ayurvedic claims of systemic benefits. This review synthesizes current knowledge linking Ayurveda with microbiome science, outlines mechanistic pathways, discusses translational opportunities in metabolic, gastrointestinal, and neuropsychiatric disorders, and highlights methodological challenges. Finally, it proposes a roadmap integrating Ayurvedic wisdom with multi-omics, computational biology, and precision medicine approaches to advance personalized microbiome-Ayurveda therapeutics.
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