FHIR-Powered Intelligence: Cloud and AI for Next-Gen Healthcare

Authors

  • Somnath Mahale Independent Data & AI Consultant, Pune, 411015 Author

Abstract

Healthcare data has long been locked in silos—fragmented across electronic health records, registries, laboratories, and insurance systems. This fragmentation slows patient care, complicates compliance, and prevents the timely use of analytics. In the U.S., the adoption of FHIR (Fast Healthcare Interoperability Resources) combined with cloud-native data architectures has begun to transform this reality, reducing onboarding time for new data sources, enabling real-time dashboards, and powering AI-ready datasets.

Drawing from my experience leading end-to-end healthcare data platforms, this paper presents an architectural approach to unifying disparate healthcare datasets into a FHIR-native clinical data repository deployed on Google Cloud Platform. I illustrate implementation through concrete use cases—preventive screening, immunization compliance, and AI enablement—and share results that demonstrate reduced latency, compliance-by-design, and improved clinical impact.

The analysis extends beyond the U.S. by examining India’s digital health journey, where national initiatives like the Ayushman Bharat Digital Mission (ABDM) and National Health Claim Exchange (NHCX) are embedding FHIR at the core of a digital public good. By comparing U.S. and Indian contexts, I highlight both challenges and opportunities for scaling interoperability, compliance, and intelligence globally. The paper concludes by looking ahead to future directions—multimodal integration, federated learning, and cross-border health data exchange—positioning FHIR as the foundation for a new era of healthcare intelligence.

References

1. Torab-Miandoab A, Samad-Soltani T, Jodati A, Rezaei-Hachesu P. Interoperability of heterogeneous health information systems: a systematic literature review. BMC Med Inform Decis Mak. 2023;23(1):18. https://doi.org/10.1186/s12911-023-02115-5

2. Ayaz M, Pasha MF, Alzahrani MY, Budiarto R, Stiawan D. The Fast Health Interoperability Resources (FHIR) standard: systematic literature review of implementations, applications, challenges and opportunities. JMIR Med informatics. 2021;9(7):e21929. https://doi.org/10.2196/21929

3. Adler-Milstein J, Jha AK. HITECH Act drove large gains in hospital electronic health record adoption. Health Aff. 2017;36(8):1416–22. https://doi.org/10.1377/hlthaff.2016.1651

4. Raghupathi W, Raghupathi V. Big data analytics in healthcare: promise and potential. Heal Inf Sci Syst. 2014;2(1):3. https://doi.org/10.1186/2047-2501-2-3

5. HL7 International [Internet]. 2023 [cited 2025 Sep 23]. FHIR Release 4 Specification. Available from: https://hl7.org/fhir/ [accessed on 23 September 2025].

6. Mandel JC, Kreda DA, Mandl KD, Kohane IS, Ramoni RB. SMART on FHIR: a standards-based, interoperable apps platform for electronic health records. J Am Med Informatics Assoc. 2016;23(5):899–908. https://doi.org/10.1093/jamia/ocv189

7. Zao JKK, Wu JTS, Kanyimbo K, Delizy F, Gan TT, Kuo HI, et al. Design of a Trustworthy Cloud-Native National Digital Health Information Infrastructure for Secure Data Management and Use. Oxford Open Digit Heal. 2024;2:oqae043. https://doi.org/10.1093/oodh/oqae043

8. Hong J, Morris P, Seo J. Interconnected personal health record ecosystem using IoT cloud platform and HL7 FHIR. In: 2017 IEEE international conference on healthcare informatics (ICHI). IEEE; 2017. p. 362–7. https://doi.org/10.1109/ICHI.2017.82

9. Sharma RS, Rohatgi A, Jain S, Singh D. The Ayushman Bharat Digital Mission (ABDM): making of India’s digital health story. CSI Trans ICT. 2023;11(1):3–9. https://doi.org/10.1007/s40012-023-00375-0

10. Benson T, Grieve G. Principles of health interoperability: SNOMED CT, HL7 and FHIR. Vol. 3. Springer; 2016. https://doi.org/10.1007/978-3-319-30370-3

11. Jiang M, Wu L, Lin L, Xu Q, Zhang W, Wu Z. Cloud-native-based flexible value generation mechanism of public health platform using machine learning. Neural Comput Appl. 2023;35(3):2103–17. https://doi.org/10.1007/s00521-022-07221-5

12. Zahoor I, Singh S, Behl T, Sharma N, Naved T, Subramaniyan V, et al. Emergence of microneedles as a potential therapeutics in diabetes mellitus. Environ Sci Pollut Res. 2021;1–21. https://doi.org/10.1007/s11356-021-17346-0

13. Sherman RE, Anderson SA, Dal Pan GJ, Gray GW, Gross T, Hunter NL, et al. Real-world evidence—what is it and what can it tell us. N Engl J Med. 2016;375(23):2293–7. https://doi.org/10.1056/NEJMsb1609216

14. Chahal CAA, Alahdab F, Asatryan B, Addison D, Aung N, Chung MK, et al. Data Interoperability and Harmonization in Cardiovascular Genomic and Precision Medicine. Circ Genomic Precis Med. 2025;e004624. https://doi.org/10.1161/CIRCGEN.124.004624

15. Kaissis GA, Makowski MR, Rückert D, Braren RF. Secure, privacy-preserving and federated machine learning in medical imaging. Nat Mach Intell. 2020;2(6):305–11. https://doi.org/10.1038/s42256-020-0186-1

16. Nalin M, Baroni I, Faiella G, Romano M, Matrisciano F, Gelenbe E, et al. The European cross-border health data exchange roadmap: Case study in the Italian setting. J Biomed Inform. 2019;94:103183. https://doi.org/10.1016/j.jbi.2019.103183

Downloads

Published

2025-10-03

How to Cite

FHIR-Powered Intelligence: Cloud and AI for Next-Gen Healthcare. (2025). Insights of Pharmatech, 1, 2-5. https://amepurvapub.com/index.php/InsightsPharmatech/article/view/29