Long-Acting Injectable and Implantable Dosage Forms: A Paradigm Shift in Chronic Disease Therapy

Abstract

The global burden of chronic diseases such as diabetes, HIV, schizophrenia, and hormonal imbalances continues to grow,
placing immense pressure on healthcare systems and patients alike. Traditional oral or short-acting parenteral therapies
are often hindered by poor adherence, leading to suboptimal outcomes, resistance development, and increased morbidity.
Long-acting injectable and implantable dosage forms offer a transformative approach to overcoming these limitations. By
providing sustained therapeutic effects over extended periods, these delivery systems represent a significant advancement
in chronic disease management. This review explores the principles, mechanisms, clinical applications, benefits, limitations,
and future potential of these advanced drug delivery platforms